Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera.

Journal Article (Journal Article)

Bacterial lipopolysaccharides (LPS) derived from a variety of organisms effectively induced C consumption in humans, bovines, and porcines with developmental agammaglobulinemia; birds with experimental agammaglobulinemia; and humans with agammaglobulinemia syndromes. This interaction proceeded even in precolostral piglet sera which contained less than 2.5 x 10(-6) mg/ml gamma globulin, and led to generation of neutrophil chemotactic factor and anaphylatoxin in these sera. Hence, the LPS-C interaction can proceed in sera markedly deficient in immunoglobulin. The question of whether immunoglobulins can be bypassed in the LPS-C interaction, or whether they are regularly utilized in a way so efficient that their participation is masked, was considered.

Full Text

Duke Authors

Cited Authors

  • Gewurz, H; Pickering, RJ; Snyderman, R; Lichtenstein, LM; Good, RA; Mergenhagen, SE

Published Date

  • April 1, 1970

Published In

Volume / Issue

  • 131 / 4

Start / End Page

  • 817 - 831

PubMed ID

  • 4193936

Pubmed Central ID

  • PMC2138773

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.131.4.817


  • eng

Conference Location

  • United States