Decreased C'-1q protein concentration and agglutinating activity in agammaglobulinaemia syndromes: an inborn error reflected in the complement system.

Journal Article (Journal Article)

In both C'1q protein and agglutination assays, markedly reduced mean titres (27 and <10% normal, respectively) were observed in Swiss type lymphopenic agammaglobulinaemia. Mean C'1q titres were somewhat decreased in other forms of agammaglobulinaemia, but not to the same degree (78 and 46% normal, respectively). C'1q titres were normal or elevated in other diseases associated with repeated infections and malignancy. We conclude that the C'1q globulins, like the immunoglobulins, characteristically are deficient in agammaglobulinaemia syndromes. Since the greatest C'1q deficiencies were seen in lymphopenic agammaglobulinaemia of the Swiss type, titration of C'1q seems to be a convenient aid in diagnosing this disease early in life. Thus, the inborn error of agammaglobulinaemia seems to be reflected in the complement system.

Full Text

Duke Authors

Cited Authors

  • Gewurz, H; Pickering, RJ; Christian, CL; Snyderman, R; Mergenhagen, SE; Good, RA

Published Date

  • June 1, 1968

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 437 - 445

PubMed ID

  • 5662582

Pubmed Central ID

  • PMC1578905

International Standard Serial Number (ISSN)

  • 0009-9104

Language

  • eng

Conference Location

  • England