Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling.

Journal Article (Journal Article;Review)

The seemingly simple structure of the actin filament belies the elaborate signaling pathways that regulate its assembly and disassembly in eukaryotic cells. In retrospect, this signaling complexity should not be surprising. Actin regulates many dynamic cellular processes, including protein and organelle trafficking, establishment of cell polarity, directional migration, cellular traction, and the efficiency of endocytosis. Signaling events that coordinately control actin turnover during these processes must display a high degree of sophistication. Emerging data on an important regulator of actin dynamics, the actin-related protein 2 and 3 (Arp2/3) complex, suggest a model of how this may occur.

Full Text

Duke Authors

Cited Authors

  • Soderling, SH

Published Date

  • January 27, 2009

Published In

Volume / Issue

  • 2 / 55

Start / End Page

  • pe5 -

PubMed ID

  • 19176514

Pubmed Central ID

  • PMC2805900

Electronic International Standard Serial Number (EISSN)

  • 1937-9145

Digital Object Identifier (DOI)

  • 10.1126/scisignal.255pe5


  • eng

Conference Location

  • United States