WAVE signalling: from biochemistry to biology.

Journal Article (Journal Article;Review)

The small GTPases Rho, Rac and Cdc42 (cell-division cycle 42) function as molecular switches to modulate the actin cytoskeleton. They achieve this by modulating the activity of downstream cellular targets. One group of Rho GTPase effectors, WAVE (Wiskott-Aldrich syndrome protein verprolin homologous)-1, WAVE-2 and WAVE-3, function as scaffolds for actin-based signalling complexes. The present review highlights current knowledge regarding the biochemistry of the WAVE signalling complexes and their biological significance.

Full Text

Duke Authors

Cited Authors

  • Soderling, SH; Scott, JD

Published Date

  • February 2006

Published In

Volume / Issue

  • 34 / Pt 1

Start / End Page

  • 73 - 76

PubMed ID

  • 16417486

International Standard Serial Number (ISSN)

  • 0300-5127

Digital Object Identifier (DOI)

  • 10.1042/BST0340073


  • eng

Conference Location

  • England