Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.

Published

Journal Article

The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.

Full Text

Duke Authors

Cited Authors

  • Soderling, SH; Langeberg, LK; Soderling, JA; Davee, SM; Simerly, R; Raber, J; Scott, JD

Published Date

  • February 18, 2003

Published In

Volume / Issue

  • 100 / 4

Start / End Page

  • 1723 - 1728

PubMed ID

  • 12578964

Pubmed Central ID

  • 12578964

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0438033100

Language

  • eng

Conference Location

  • United States