Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.

Journal Article (Journal Article;Review)

The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered and characterized. In addition, several new highly specific PDE inhibitors have been developed and approved for clinical use. Finally, new strategies have been employed to determine PDE function in model systems including the use of antisense oligonucleotide and disruption techniques.

Full Text

Duke Authors

Cited Authors

  • Soderling, SH; Beavo, JA

Published Date

  • April 2000

Published In

Volume / Issue

  • 12 / 2

Start / End Page

  • 174 - 179

PubMed ID

  • 10712916

International Standard Serial Number (ISSN)

  • 0955-0674

Digital Object Identifier (DOI)

  • 10.1016/s0955-0674(99)00073-3


  • eng

Conference Location

  • England