Spin-echo magnetic resonance spectroscopic imaging at 7 T with frequency-modulated refocusing pulses.

Journal Article (Journal Article)

Two approaches to high-resolution SENSE-encoded magnetic resonance spectroscopic imaging (MRSI) of the human brain at 7 Tesla (T) with whole-slice coverage are described. Both sequences use high-bandwidth radiofrequency pulses to reduce chemical shift displacement artifacts, SENSE-encoding to reduce scan time, and dual-band water and lipid suppression optimized for 7 T. Simultaneous B0 and transmit B1 mapping was also used for both sequences to optimize field homogeneity using high-order shimming and determine optimum radiofrequency transmit level, respectively. One sequence ("Hahn-MRSI") used reduced flip angle (90°) refocusing pulses for lower radiofrequency power deposition, while the other sequence used adiabatic fast passage refocusing pulses for improved sensitivity and reduced signal dependence on the transmit-B1 level. In four normal subjects, adiabatic fast passage-MRSI showed a signal-to-noise ratio improvement of 3.2±0.5 compared to Hahn-MRSI at the same spatial resolution, pulse repetition time, echo time, and SENSE-acceleration factor. An interleaved two-slice Hahn-MRSI sequence is also demonstrated to be experimentally feasible.

Full Text

Duke Authors

Cited Authors

  • Zhu, H; Soher, BJ; Ouwerkerk, R; Schär, M; Barker, PB

Published Date

  • May 2013

Published In

Volume / Issue

  • 69 / 5

Start / End Page

  • 1217 - 1225

PubMed ID

  • 22692894

Pubmed Central ID

  • PMC3443531

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

Digital Object Identifier (DOI)

  • 10.1002/mrm.24357


  • eng

Conference Location

  • United States