Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity.

Journal Article (Journal Article)

This work describes the use of magnetic resonance (MR) microscopy to examine changes in tibial trabecular bone structure in mice following 28 days of hindlimb suspension, a model simulating the effects of microgravity in rodents. In this first MR study involving mice, analysis of 3D images showed that apparent bone volume fraction, trabecular number, and trabecular thickness were decreased, and apparent trabecular spacing increased, significantly (P < 0.05) in hindlimb-suspended mice compared to controls. These changes agreed well with light microscopy measurements from an independent study and also with actual spaceflight experiments with rats.

Full Text

Duke Authors

Cited Authors

  • Gardner, JR; Hess, CP; Webb, AG; Tsika, RW; Dawson, MJ; Gulani, V

Published Date

  • June 2001

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 1122 - 1125

PubMed ID

  • 11378892

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1148


  • eng

Conference Location

  • United States