Whole-cell membrane current and membrane resistance during hypoxic spreading depression.


Journal Article

In rat hippocampal tissue slices we recorded extracellular potential (Vo) and whole-cell patch clamp current of CA1 pyramid cells. During hypoxic spreading depression (SD)-like depolarization, the holding current (Ih) increased sharply. Membrane 'slope' resistance (Rm) decreased to 10-67% (mean 39%) of the resting value. The SD-related membrane current (ISD) reversed near zero mV. With voltage dependent K+ and Na+ currents blocked by Cs+ and QX-314, shifts of Ih and decrease of Rm during SD were not suppressed. We conclude that hypoxic SD of CA1 pyramidal cells is associated with a large non-selective inward current through yet to be identified membrane mechanisms, which cannot fully explain the SD-related Vo shift.

Full Text

Duke Authors

Cited Authors

  • Czéh, G; Aitken, PG; Somjen, GG

Published Date

  • February 1, 1992

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 197 - 200

PubMed ID

  • 1623173

Pubmed Central ID

  • 1623173

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199202000-00019


  • eng

Conference Location

  • England