Calcium, magnesium, and long-term recovery from hypoxia in hippocampal tissue slices.


Journal Article

Ortho- and antidromic responses recovered and remained robust for 5 h in slices exposed to transient hypoxia in low calcium, while responses remained depressed in slices made hypoxic in normal calcium. Elevating magnesium in addition to reducing calcium did not improve recovery compared to reducing calcium alone. Spreading depression-like hypoxic depolarization occurred earlier in low calcium than in control fluid. We conclude that loss of function was triggered by calcium uptake by neurons and not by cell swelling, and that activation of NMDA receptors probably played no part.

Full Text

Duke Authors

Cited Authors

  • Young, JN; Aitken, PG; Somjen, GG

Published Date

  • May 10, 1991

Published In

Volume / Issue

  • 548 / 1-2

Start / End Page

  • 343 - 345

PubMed ID

  • 1868344

Pubmed Central ID

  • 1868344

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(91)91146-r


  • eng

Conference Location

  • Netherlands