Hyperexcitability following moderate hypoxia in hippocampal tissue slices.


Journal Article

The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 degrees C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.

Full Text

Duke Authors

Cited Authors

  • Schiff, SJ; Somjen, GG

Published Date

  • July 1, 1985

Published In

Volume / Issue

  • 337 / 2

Start / End Page

  • 337 - 340

PubMed ID

  • 2992681

Pubmed Central ID

  • 2992681

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)90071-x


  • eng

Conference Location

  • Netherlands