Overshoot of oxygen pressure in post-hypoxic brain tissue: a re-evaluation.


Journal Article

Tissue oxygen pressure (ptO2) was measured with noble metal microelectrodes in hippocampal slices in vitro. During hypoxia, the ptO2 at 100 micron depth fell rapidly to less than 20 mm Hg. During reoxygenation, large transient ptO2 increases above normoxic values were observed. These data demonstrate that ptO2 'overshoots' occur independently of in situ posthypoxic hyperemia and may reflect pathologic chemical reactions in brain tissue during reoxygenation.

Full Text

Duke Authors

Cited Authors

  • Schiff, SJ; Somjen, GG

Published Date

  • September 30, 1985

Published In

Volume / Issue

  • 344 / 1

Start / End Page

  • 150 - 153

PubMed ID

  • 4041862

Pubmed Central ID

  • 4041862

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(85)91200-4


  • eng

Conference Location

  • Netherlands