Treatment of metastatic ErbB2-positive breast cancer: Options after progression on trastuzumab


Journal Article

Although trastuzumab-based therapy has changed the treatment paradigm for ErbB2-positive breast cancers, most patients eventually develop progressive disease. Of particular interest is the issue of disease progression in the central nervous system, a safe haven from high molecular weight antibodies like trastuzumab, which have limited ability to cross the blood-brain barrier. This review will discuss therapeutic options for when disease progression has occurred on trastuzumab-based therapies, including central nervous system progression, continuation of trastuzumab-based therapy, addition of novel targeted therapies, and the use of small-molecule tyrosine kinase inhibitors targeting ErbB receptors.

Full Text

Duke Authors

Cited Authors

  • Spector, N

Published Date

  • January 1, 2008

Published In

Volume / Issue

  • 8 / SUPPL. 3

International Standard Serial Number (ISSN)

  • 1526-8209

Digital Object Identifier (DOI)

  • 10.3816/CBC.2008.s.005

Citation Source

  • Scopus