Nmr investigation of a microtubule binding region peptide from human tau (τ) protein
Solution NMR studies of τD1, an 18-residue microtubule binding peptide from domain 1 of human tau protein, are reported. Using 2D 1H NMR (TOCSY, NOESY and ROESY) at 5 and 37°C, we assigned the resonances of almost all protons of τD1 at pH 4.2,5.8 and 7.3. While overall the peptide is highly disordered, several medium range NOE's give evidence for conformational preferences involving a bend at the T8-Q14 segment of the peptide.
De Serrano, V; Ribeiro, AA; Strittmatter, WJ; Spicer, LD
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