Direct incorporation of [11 C]carbon dioxide for labeling bioactive molecules. An application to [11 C] labeled tamoxifen


Journal Article

A one‐pot synthesis of [11C] labeled tamoxifen has been developed via reductive carboxylation. In this approach, [11C]CO2 is reacted with the N‐trimethylsilyl derivative of desmethyltamoxifen, followed by in situ sodium bis (2‐methoxyethoxy)aluminum hydride reduction, to afford impure [11C] labeled tamoxifen, which, on purification over a basic alumina‐silica gel column, provided pure [11C] tamoxifen in excellent radiochemical yield (65% to 84%) and radiochemical purity (>99%). The specific activity of [11C]tamoxifen was 250–400 Ci/mmol at the end of bombardment. Copyright © 1989 John Wiley & Sons, Ltd.

Full Text

Duke Authors

Cited Authors

  • Ram, S; Spicer, LD

Published Date

  • January 1, 1989

Published In

Volume / Issue

  • 27 / 6

Start / End Page

  • 661 - 668

Electronic International Standard Serial Number (EISSN)

  • 1099-1344

International Standard Serial Number (ISSN)

  • 0362-4803

Digital Object Identifier (DOI)

  • 10.1002/jlcr.2580270608

Citation Source

  • Scopus