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Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis.

Publication ,  Journal Article
West, KL; Sporn, T; Puri, PK
Published in: Arch Dermatol
February 2012

BACKGROUND: Multicentric reticulohistiocytosis (MRH) is a rare disease of uncertain etiology that most commonly presents as a papulonodular cutaneous eruption accompanied by erosive polyarthritis. Although MRH is considered a systemic disorder in that it targets skin and joints, involvement of thoracic and visceral organs is uncommon. OBSERVATIONS: A woman presented with diffuse cutaneous nodules, and skin biopsy findings revealed classic features of MRH. However, she also manifested severe pulmonary symptoms. A lung biopsy specimen showed prominent histiocytic infiltrates exhibiting the same characteristic morphologic features as those seen in her skin. Furthermore, the lung biopsy findings were significant for a pattern of usual interstitial pneumonia accompanied by notable lymphoid aggregates, a pattern of interstitial lung disease typical of systemic autoimmune and inflammatory conditions. CONCLUSIONS: These findings are notable because a histiocytic pulmonary infiltrate suggestive of direct pulmonary involvement by MRH is a rare event. In addition, presentation of MRH in the setting of usual interstitial pneumonia is unique. These observations document a new clinical and histopathologic presentation of MRH that is significant for expanding the idea of MRH as a systemic disease while supporting the notion that MRH is promoted by an inflammatory milieu.

Duke Scholars

Published In

Arch Dermatol

DOI

EISSN

1538-3652

Publication Date

February 2012

Volume

148

Issue

2

Start / End Page

228 / 232

Location

United States

Related Subject Headings

  • Skin Diseases
  • Middle Aged
  • Idiopathic Pulmonary Fibrosis
  • Humans
  • Histiocytosis
  • Female
  • Diagnosis, Differential
  • Dermatology & Venereal Diseases
  • Arthritis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
West, K. L., Sporn, T., & Puri, P. K. (2012). Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. Arch Dermatol, 148(2), 228–232. https://doi.org/10.1001/archdermatol.2011.1331
West, Kelly L., Tom Sporn, and Puja K. Puri. “Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis.Arch Dermatol 148, no. 2 (February 2012): 228–32. https://doi.org/10.1001/archdermatol.2011.1331.
West KL, Sporn T, Puri PK. Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. Arch Dermatol. 2012 Feb;148(2):228–32.
West, Kelly L., et al. “Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis.Arch Dermatol, vol. 148, no. 2, Feb. 2012, pp. 228–32. Pubmed, doi:10.1001/archdermatol.2011.1331.
West KL, Sporn T, Puri PK. Multicentric reticulohistiocytosis: a unique case with pulmonary fibrosis. Arch Dermatol. 2012 Feb;148(2):228–232.

Published In

Arch Dermatol

DOI

EISSN

1538-3652

Publication Date

February 2012

Volume

148

Issue

2

Start / End Page

228 / 232

Location

United States

Related Subject Headings

  • Skin Diseases
  • Middle Aged
  • Idiopathic Pulmonary Fibrosis
  • Humans
  • Histiocytosis
  • Female
  • Diagnosis, Differential
  • Dermatology & Venereal Diseases
  • Arthritis
  • 3202 Clinical sciences