A prototype two-partner secretion pathway: the Haemophilus influenzae HMW1 and HMW2 adhesin systems.


Journal Article (Review)

Nontypable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract. Adherence to respiratory epithelium is an important step in the process of colonization and is influenced by adhesive proteins called adhesins. In approximately 80% of nontypable H. influenzae isolates, the major adhesins are related proteins called HMW1 and HMW2. Here, we summarize recent advances in our understanding of HMW1 and HMW2 as prototype members of the bacterial two-partner secretion pathway and examples of the expanding number of bacterial glycoproteins, highlighting experimental approaches that might be useful in studies of other secreted proteins and glycoproteins.

Full Text

Cited Authors

  • St Geme, JW; Yeo, H-J

Published Date

  • August 5, 2009

Published In

Volume / Issue

  • 17 / 8

Start / End Page

  • 355 - 360

PubMed ID

  • 19660953

Pubmed Central ID

  • 19660953

Electronic International Standard Serial Number (EISSN)

  • 1878-4380

International Standard Serial Number (ISSN)

  • 0966-842X

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2009.06.002


  • eng