Molecular and cellular determinants of non-typeable Haemophilus influenzae adherence and invasion.


Journal Article (Review)

Non-typeable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract. Based on information from histopathologic specimens and in vitro studies with human cells and tissues in culture, non-typeable H. influenzae is capable of efficient adherence and appreciable invasion, properties that facilitate the process of colonization. A number of adhesive factors exist, each recognizing a distinct host cell structure and influencing cellular binding specificity. In addition, at least three invasion pathways exist, including one resembling macropinocytosis, a second mediated via the PAF receptor and a third involving beta-glucan receptors. Organisms are also capable of disrupting cell-cell junctions and passing between cells to the subepithelial space.

Full Text

Cited Authors

  • St Geme, JW

Published Date

  • April 2002

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 191 - 200

PubMed ID

  • 11952636

Pubmed Central ID

  • 11952636

Electronic International Standard Serial Number (EISSN)

  • 1462-5822

International Standard Serial Number (ISSN)

  • 1462-5814

Digital Object Identifier (DOI)

  • 10.1046/j.1462-5822.2002.00180.x


  • eng