Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.


Journal Article (Review)

Secretion of proteins by the general secretory pathway (GSP) is a two-step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence.

Full Text

Cited Authors

  • Stathopoulos, C; Hendrixson, DR; Thanassi, DG; Hultgren, SJ; St Geme, JW; Curtiss, R

Published Date

  • July 2000

Published In

Volume / Issue

  • 2 / 9

Start / End Page

  • 1061 - 1072

PubMed ID

  • 10967286

Pubmed Central ID

  • 10967286

Electronic International Standard Serial Number (EISSN)

  • 1769-714X

International Standard Serial Number (ISSN)

  • 1286-4579

Digital Object Identifier (DOI)

  • 10.1016/s1286-4579(00)01260-0


  • eng