Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.
Publication
, Journal Article
Stathopoulos, C; Hendrixson, DR; Thanassi, DG; Hultgren, SJ; St Geme, JW; Curtiss, R
Published in: Microbes and infection
July 2000
Secretion of proteins by the general secretory pathway (GSP) is a two-step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence.
Published In
Microbes and infection
DOI
EISSN
1769-714X
ISSN
1286-4579
Publication Date
July 2000
Volume
2
Issue
9
Start / End Page
1061 / 1072
Related Subject Headings
- Virulence
- Structure-Activity Relationship
- SecA Proteins
- SEC Translocation Channels
- Molecular Chaperones
- Microbiology
- Membrane Transport Proteins
- Gram-Negative Bacteria
- Glycoside Hydrolases
- Fimbriae, Bacterial
Citation
APA
Chicago
ICMJE
MLA
NLM
Stathopoulos, C., Hendrixson, D. R., Thanassi, D. G., Hultgren, S. J., St Geme, J. W., & Curtiss, R. (2000). Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and Infection, 2(9), 1061–1072. https://doi.org/10.1016/s1286-4579(00)01260-0
Stathopoulos, C., D. R. Hendrixson, D. G. Thanassi, S. J. Hultgren, J. W. St Geme, and R. Curtiss. “Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.” Microbes and Infection 2, no. 9 (July 2000): 1061–72. https://doi.org/10.1016/s1286-4579(00)01260-0.
Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW, Curtiss R. Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and infection. 2000 Jul;2(9):1061–72.
Stathopoulos, C., et al. “Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.” Microbes and Infection, vol. 2, no. 9, July 2000, pp. 1061–72. Epmc, doi:10.1016/s1286-4579(00)01260-0.
Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW, Curtiss R. Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and infection. 2000 Jul;2(9):1061–1072.
Published In
Microbes and infection
DOI
EISSN
1769-714X
ISSN
1286-4579
Publication Date
July 2000
Volume
2
Issue
9
Start / End Page
1061 / 1072
Related Subject Headings
- Virulence
- Structure-Activity Relationship
- SecA Proteins
- SEC Translocation Channels
- Molecular Chaperones
- Microbiology
- Membrane Transport Proteins
- Gram-Negative Bacteria
- Glycoside Hydrolases
- Fimbriae, Bacterial