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Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.

Publication ,  Journal Article
Stathopoulos, C; Hendrixson, DR; Thanassi, DG; Hultgren, SJ; St Geme, JW; Curtiss, R
Published in: Microbes and infection
July 2000

Secretion of proteins by the general secretory pathway (GSP) is a two-step process requiring the Sec translocase in the inner membrane and a separate substrate-specific secretion apparatus for translocation across the outer membrane. Gram-negative bacteria with pathogenic potential use the GSP to deliver virulence factors into the extracellular environment for interaction with the host. Well-studied examples of virulence determinants using the GSP for secretion include extracellular toxins, pili, curli, autotransporters, and crystaline S-layers. This article reviews our current understanding of the GSP and discusses examples of terminal branches of the GSP which are utilized by factors implicated in bacterial virulence.

Published In

Microbes and infection

DOI

EISSN

1769-714X

ISSN

1286-4579

Publication Date

July 2000

Volume

2

Issue

9

Start / End Page

1061 / 1072

Related Subject Headings

  • Virulence
  • Structure-Activity Relationship
  • SecA Proteins
  • SEC Translocation Channels
  • Molecular Chaperones
  • Microbiology
  • Membrane Transport Proteins
  • Gram-Negative Bacteria
  • Glycoside Hydrolases
  • Fimbriae, Bacterial
 

Citation

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MLA
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Stathopoulos, C., Hendrixson, D. R., Thanassi, D. G., Hultgren, S. J., St Geme, J. W., & Curtiss, R. (2000). Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and Infection, 2(9), 1061–1072. https://doi.org/10.1016/s1286-4579(00)01260-0
Stathopoulos, C., D. R. Hendrixson, D. G. Thanassi, S. J. Hultgren, J. W. St Geme, and R. Curtiss. “Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.Microbes and Infection 2, no. 9 (July 2000): 1061–72. https://doi.org/10.1016/s1286-4579(00)01260-0.
Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW, Curtiss R. Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and infection. 2000 Jul;2(9):1061–72.
Stathopoulos, C., et al. “Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story.Microbes and Infection, vol. 2, no. 9, July 2000, pp. 1061–72. Epmc, doi:10.1016/s1286-4579(00)01260-0.
Stathopoulos C, Hendrixson DR, Thanassi DG, Hultgren SJ, St Geme JW, Curtiss R. Secretion of virulence determinants by the general secretory pathway in gram-negative pathogens: an evolving story. Microbes and infection. 2000 Jul;2(9):1061–1072.
Journal cover image

Published In

Microbes and infection

DOI

EISSN

1769-714X

ISSN

1286-4579

Publication Date

July 2000

Volume

2

Issue

9

Start / End Page

1061 / 1072

Related Subject Headings

  • Virulence
  • Structure-Activity Relationship
  • SecA Proteins
  • SEC Translocation Channels
  • Molecular Chaperones
  • Microbiology
  • Membrane Transport Proteins
  • Gram-Negative Bacteria
  • Glycoside Hydrolases
  • Fimbriae, Bacterial