Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.

Published

Journal Article

The immunotherapeutic potential of a monoclonal antibody specific for glycoprotein D of herpes simplex virus was evaluated in a murine ocular infection model. Passive transfer of antibody at microgram concentrations was able to promote resolution of corneal opacity and hasten healing of blepharitis. Antibody treatment did not prevent development of either a cellular or humoral antiviral immune response. In fact, kinetic studies revealed that the early delayed-type hypersensitivity response was significantly more vigorous in the treated group than in the controls. Potential explanations as to how a single microgram inoculation of antibody could exert a therapeutic effect are discussed.

Full Text

Duke Authors

Cited Authors

  • Lausch, RN; Staats, H; Metcalf, JF; Oakes, JE

Published Date

  • 1990

Published In

Volume / Issue

  • 31 / 2-4

Start / End Page

  • 159 - 165

PubMed ID

  • 2373609

Pubmed Central ID

  • 2373609

International Standard Serial Number (ISSN)

  • 0300-5526

Digital Object Identifier (DOI)

  • 10.1159/000150150

Language

  • eng

Conference Location

  • Switzerland