Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.
Publication
, Journal Article
Lausch, RN; Staats, H; Metcalf, JF; Oakes, JE
Published in: Intervirology
1990
The immunotherapeutic potential of a monoclonal antibody specific for glycoprotein D of herpes simplex virus was evaluated in a murine ocular infection model. Passive transfer of antibody at microgram concentrations was able to promote resolution of corneal opacity and hasten healing of blepharitis. Antibody treatment did not prevent development of either a cellular or humoral antiviral immune response. In fact, kinetic studies revealed that the early delayed-type hypersensitivity response was significantly more vigorous in the treated group than in the controls. Potential explanations as to how a single microgram inoculation of antibody could exert a therapeutic effect are discussed.
Duke Scholars
Published In
Intervirology
DOI
ISSN
0300-5526
Publication Date
1990
Volume
31
Issue
2-4
Start / End Page
159 / 165
Location
Switzerland
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Mice, Inbred BALB C
- Mice
- Kinetics
- Keratitis, Dendritic
- Immunotherapy
- Immunization, Passive
- Immunity, Cellular
- Hypersensitivity, Delayed
Citation
APA
Chicago
ICMJE
MLA
NLM
Lausch, R. N., Staats, H., Metcalf, J. F., & Oakes, J. E. (1990). Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. Intervirology, 31(2–4), 159–165. https://doi.org/10.1159/000150150
Lausch, R. N., H. Staats, J. F. Metcalf, and J. E. Oakes. “Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.” Intervirology 31, no. 2–4 (1990): 159–65. https://doi.org/10.1159/000150150.
Lausch RN, Staats H, Metcalf JF, Oakes JE. Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. Intervirology. 1990;31(2–4):159–65.
Lausch, R. N., et al. “Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response.” Intervirology, vol. 31, no. 2–4, 1990, pp. 159–65. Pubmed, doi:10.1159/000150150.
Lausch RN, Staats H, Metcalf JF, Oakes JE. Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. Intervirology. 1990;31(2–4):159–165.
Published In
Intervirology
DOI
ISSN
0300-5526
Publication Date
1990
Volume
31
Issue
2-4
Start / End Page
159 / 165
Location
Switzerland
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Mice, Inbred BALB C
- Mice
- Kinetics
- Keratitis, Dendritic
- Immunotherapy
- Immunization, Passive
- Immunity, Cellular
- Hypersensitivity, Delayed