Istradefylline for the treatment of Parkinson's disease.


Journal Article (Review)

INTRODUCTION: Despite several available therapeutic options to treat the symptoms of Parkinson's disease (PD), there are currently no agents that halt or slow the progression of disease. Istradefylline is a selective adenosine A(2A) antagonist that is currently of interest for the treatment of motor complications in PD. AREAS COVERED: This paper reviews the limitations of currently available treatment options and discusses the results seen in both animal models and human clinical trials that have explored the benefits of istradefylline in PD. EXPERT OPINION: The studies outlined continue to suggest that istradefylline may be a promising non-dopaminergic therapy for the treatment of PD. It has not been proven to be more efficacious than other currently available dopaminergic drugs, nor has it been shown to be of significant benefit as monotherapy; however, it seems to be a safe and well-tolerated drug that may help with wearing-off fluctuations. Istradefylline is not yet an FDA-approved drug. At this time, the potential for approval in the US or through the European Medical Agency remains unknown.

Full Text

Cited Authors

  • Park, A; Stacy, M

Published Date

  • January 2012

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 111 - 114

PubMed ID

  • 22149371

Pubmed Central ID

  • 22149371

Electronic International Standard Serial Number (EISSN)

  • 1744-7666

International Standard Serial Number (ISSN)

  • 1465-6566

Digital Object Identifier (DOI)

  • 10.1517/14656566.2012.643869


  • eng