Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study.


Journal Article

A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.

Full Text

Cited Authors

  • Weintraub, D; Sohr, M; Potenza, MN; Siderowf, AD; Stacy, M; Voon, V; Whetteckey, J; Wunderlich, GR; Lang, AE

Published Date

  • December 2010

Published In

Volume / Issue

  • 68 / 6

Start / End Page

  • 963 - 968

PubMed ID

  • 21154480

Pubmed Central ID

  • 21154480

Electronic International Standard Serial Number (EISSN)

  • 1531-8249

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.22164


  • eng