Impulsive and compulsive behaviors in Parkinson's disease.


Journal Article (Review)

Antiparkinson therapy can be the primary cause of a range of nonmotor symptoms that include a set of complex disinhibitory psychomotor pathologies and are linked by their repetitive, reward or incentive-based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine dysregulation syndrome (DDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, and compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug-related compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders.

Full Text

Cited Authors

  • Evans, AH; Strafella, AP; Weintraub, D; Stacy, M

Published Date

  • August 2009

Published In

Volume / Issue

  • 24 / 11

Start / End Page

  • 1561 - 1570

PubMed ID

  • 19526584

Pubmed Central ID

  • 19526584

Electronic International Standard Serial Number (EISSN)

  • 1531-8257

International Standard Serial Number (ISSN)

  • 0885-3185

Digital Object Identifier (DOI)

  • 10.1002/mds.22505


  • eng