Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results.

Published

Journal Article

We present a clinimetric assessment of the Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS). The MDS-UDPRS Task Force revised and expanded the UPDRS using recommendations from a published critique. The MDS-UPDRS has four parts, namely, I: Non-motor Experiences of Daily Living; II: Motor Experiences of Daily Living; III: Motor Examination; IV: Motor Complications. Twenty questions are completed by the patient/caregiver. Item-specific instructions and an appendix of complementary additional scales are provided. Movement disorder specialists and study coordinators administered the UPDRS (55 items) and MDS-UPDRS (65 items) to 877 English speaking (78% non-Latino Caucasian) patients with Parkinson's disease from 39 sites. We compared the two scales using correlative techniques and factor analysis. The MDS-UPDRS showed high internal consistency (Cronbach's alpha = 0.79-0.93 across parts) and correlated with the original UPDRS (rho = 0.96). MDS-UPDRS across-part correlations ranged from 0.22 to 0.66. Reliable factor structures for each part were obtained (comparative fit index > 0.90 for each part), which support the use of sum scores for each part in preference to a total score of all parts. The combined clinimetric results of this study support the validity of the MDS-UPDRS for rating PD.

Full Text

Cited Authors

  • Goetz, CG; Tilley, BC; Shaftman, SR; Stebbins, GT; Fahn, S; Martinez-Martin, P; Poewe, W; Sampaio, C; Stern, MB; Dodel, R; Dubois, B; Holloway, R; Jankovic, J; Kulisevsky, J; Lang, AE; Lees, A; Leurgans, S; LeWitt, PA; Nyenhuis, D; Olanow, CW; Rascol, O; Schrag, A; Teresi, JA; van Hilten, JJ; LaPelle, N; Movement Disorder Society UPDRS Revision Task Force,

Published Date

  • November 2008

Published In

Volume / Issue

  • 23 / 15

Start / End Page

  • 2129 - 2170

PubMed ID

  • 19025984

Pubmed Central ID

  • 19025984

Electronic International Standard Serial Number (EISSN)

  • 1531-8257

International Standard Serial Number (ISSN)

  • 0885-3185

Digital Object Identifier (DOI)

  • 10.1002/mds.22340

Language

  • eng