Significant linkage of Parkinson disease to chromosome 2q36-37.


Journal Article

Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.

Full Text

Cited Authors

  • Pankratz, N; Nichols, WC; Uniacke, SK; Halter, C; Rudolph, A; Shults, C; Conneally, PM; Foroud, T; Parkinson Study Group,

Published Date

  • April 2003

Published In

Volume / Issue

  • 72 / 4

Start / End Page

  • 1053 - 1057

PubMed ID

  • 12638082

Pubmed Central ID

  • 12638082

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

International Standard Serial Number (ISSN)

  • 0002-9297

Digital Object Identifier (DOI)

  • 10.1086/374383


  • eng