Forecasting methods for HIV/AIDS and aging


Journal Article

Recent treatment advances suggest that AIDS may be changing from a rapidly lethal, acute disease into a chronic disease process with lengthy periods of remission. Stochastic compartment models can describe AIDS progression, remission, and overall survival. Such models can combine multiple data sources to estimate transitions through intermediate, unobserved disease states. Age/time AIDS mortality may be combined with age/time AIDS incidence to generate an 'observed' health event distribution, using maximum likelihood estimation. The models can project the future behavior of AIDS in an aging population. Transitions among intermediate disease states (i.e., components of the disease's 'natural' and 'treatment- altered' history) can be evaluated as time-varying functions that reflect treatment efficacy. For example, the introduction of protease inhibitors to therapy with two nucleoside analogues significantly slows transitions between disease states. Persons infected, but successfully treated, may develop organ damage, neurological disorders, or cancer.

Full Text

Duke Authors

Cited Authors

  • Manton, KG; Stallard, E

Published Date

  • November 1, 1998

Published In

Volume / Issue

  • 20 / 6

Start / End Page

  • 846 - 864

International Standard Serial Number (ISSN)

  • 0164-0275

Digital Object Identifier (DOI)

  • 10.1177/0164027598206011

Citation Source

  • Scopus