Chronic disease evolution and human aging: A general model for assessing the impact of chronic disease in human populations


Journal Article

A general model of the effects of physiological aging changes and systematic selection due to death or to morbid changes in a human population is presented. Parameter estimation is conducted on large longitudinal data bases. Assuming the availability of such estimates, the model is developed in a form suitable for implementation on a microcomputer. Consideration is given to simulating the effects of chronic disease on a human population using estimated parameter values and using alternative values selected to reflect various assumptions about possible interventions. An example is developed using data from the Framingham Study of cardiovascular disease. © 1986.

Full Text

Duke Authors

Cited Authors

  • Manton, KG; Stallard, E; Woodbury, MA

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 7 / 5-8

Start / End Page

  • 1155 - 1171

International Standard Serial Number (ISSN)

  • 0270-0255

Digital Object Identifier (DOI)

  • 10.1016/0270-0255(86)90155-7

Citation Source

  • Scopus