Schlemm's canal endothelia, lymphatic, or blood vasculature?

Journal Article (Journal Article;Review)

In the human eye, the final barrier for aqueous humor to cross before returning to systemic circulation is the inner wall of Schlemm's canal. Unfortunately, the specific contribution of the inner wall to total outflow resistance in the conventional pathway is unknown in both normal and glaucomatous eyes. To better understand inner wall physiology, we contrasted it with 2 specialized continuous endothelia, initial lymphatic, and blood capillary endothelia. Specifically, we compare their developmental origin, morphology, junctional complexes, microenvironment, and physiologic responses to different biomechanical factors. Our evaluation concludes that the inner wall of Schlemm's canal is unique, sharing extraordinary characteristics with both types of specialized endothelia in addition to having distinctive features of its own.

Full Text

Duke Authors

Cited Authors

  • Ramos, RF; Hoying, JB; Witte, MH; Daniel Stamer, W

Published Date

  • June 2007

Published In

Volume / Issue

  • 16 / 4

Start / End Page

  • 391 - 405

PubMed ID

  • 17571003

International Standard Serial Number (ISSN)

  • 1057-0829

Digital Object Identifier (DOI)

  • 10.1097/IJG.0b013e3180654ac6


  • eng

Conference Location

  • United States