Corticosteroid treatment and trabecular meshwork proteases in cell and organ culture supernatants.


Journal Article

Steroid-induced glaucoma is believed to result from increased aqueous outflow resistance and evidence suggests that this is the result of an excess accumulation of extracellular matrix components. This accumulation could result from an imbalance in the natural turnover of these components. We have investigated the effect of corticosteroid treatment of trabecular meshwork (TM) organ and cell cultures on the extracellular activities of the matrix metalloproteinases and plasminogen activators. We find that corticosteroid treatment results in decreased extracellular activity of stromelysin and tissue plasminogen activator in trabecular meshwork cell culture, and decreased 92 kDa collagenase IV, stromelysin, and tissue plasminogen activator in trabecular meshwork organ culture. These data suggest that decreased levels of proteolytic activities could account, in part, for the accumulation of some extracellular matrix components and be a contributing mechanism in steroid-induced glaucoma.

Full Text

Cited Authors

  • Snyder, RW; Stamer, WD; Kramer, TR; Seftor, RE

Published Date

  • October 1993

Published In

Volume / Issue

  • 57 / 4

Start / End Page

  • 461 - 468

PubMed ID

  • 8282032

Pubmed Central ID

  • 8282032

International Standard Serial Number (ISSN)

  • 0014-4835

Digital Object Identifier (DOI)

  • 10.1006/exer.1993.1148


  • eng

Conference Location

  • England