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Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling

Publication ,  Journal Article
Cimponeriu, A; Starmer, CF; Bezerianos, A
Published in: Computers in Cardiology
December 1, 1998

In order to identify generic mechanisms for altering the ECG during ischemia, we explored changes in the action potential propagation during different ischemic conditions using simple cellular models. Based on the Beeler-Reuter and Lou-Rudy I cellular models, we developed a ventricular tissue model for probing how alterations in shape and propagation of action potential distorted the theoretical ECG signal. If arrhythmias are a characteristic of acute ischemia, the changes in ST segment duration and T wave shape seems to be related with chronic ischemia and presence of the unexcitable medium. During different stages of ischemia, the changes in theoretical ECG indicated possibilities for detecting the relation between cellular changes and external measurement of the electrical activity of the heart.

Duke Scholars

Published In

Computers in Cardiology

ISSN

0276-6574

Publication Date

December 1, 1998

Volume

0

Issue

0

Start / End Page

317 / 320

Related Subject Headings

  • Cardiovascular System & Hematology
 

Citation

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MLA
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Cimponeriu, A., Starmer, C. F., & Bezerianos, A. (1998). Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. Computers in Cardiology, 0(0), 317–320.
Cimponeriu, A., C. F. Starmer, and A. Bezerianos. “Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling.” Computers in Cardiology 0, no. 0 (December 1, 1998): 317–20.
Cimponeriu A, Starmer CF, Bezerianos A. Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. Computers in Cardiology. 1998 Dec 1;0(0):317–20.
Cimponeriu, A., et al. “Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling.” Computers in Cardiology, vol. 0, no. 0, Dec. 1998, pp. 317–20.
Cimponeriu A, Starmer CF, Bezerianos A. Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. Computers in Cardiology. 1998 Dec 1;0(0):317–320.

Published In

Computers in Cardiology

ISSN

0276-6574

Publication Date

December 1, 1998

Volume

0

Issue

0

Start / End Page

317 / 320

Related Subject Headings

  • Cardiovascular System & Hematology