Vulnerability in one-dimensional excitable media

Journal Article (Journal Article)

Potentially life-threatening cardiac arrhythmias can be iniated with stimuli timed to occur during the "vulnerable window (VW)". We defined VW as the time interval between the "conditioning" and "test" stimuli following in sequence, during which the test stimulus response propagates in only one direction. We show that the VW is a generic feature of excitable media and describe the relationship between the properties of an excitable medium and the VW. We present asymptotic results that reveal the sensitivity of the VW to both the propagation velocity of the conditioning wavefront and the recovery process parameters. We also have identified a critical length of medium that must be excited in order to reveal vulnerability. Analytical results are in agreement with numerical studies. © 1994.

Full Text

Duke Authors

Cited Authors

  • Starobin, J; Zilberter, YI; Starmer, CF

Published Date

  • February 15, 1994

Published In

Volume / Issue

  • 70 / 4

Start / End Page

  • 321 - 341

International Standard Serial Number (ISSN)

  • 0167-2789

Digital Object Identifier (DOI)

  • 10.1016/0167-2789(94)90069-8

Citation Source

  • Scopus