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MRI-defined vascular depression: a review of the construct.

Publication ,  Journal Article
Culang-Reinlieb, ME; Johnert, LC; Brickman, AM; Steffens, DC; Garcon, E; Sneed, JR
Published in: Int J Geriatr Psychiatry
November 2011

OBJECTIVE: To review the construct of MRI-defined vascular depression and to examine the substantive and methodological issues that bear on its validity as a distinct subtype of depression in late life. DESIGN: Literature review. RESULTS: We identified three areas that are critical to establishing the validity of MRI-defined vascular depression: (1) understanding and delineating the relationship between MRI hyperintensities, executive dysfunction, and antidepressant treatment outcome; (2) understanding the relationship between, and establishing the validity of, qualitative and quantitative approaches to the measurement of MRI hyperintensities (the primary feature of the proposed subtype); (3) establishing the clinical presentation and course of the subtype in the context of other late-life disorders. CONCLUSIONS: Despite considerable data supporting the validity of MRI-defined vascular depression, there are a number of critical issues that remain, including establishing a causal relationship between cerebrovascular disease and late-life depression, establishing consistent diagnostic criteria, determining the importance of lesion type and location, and understanding the course of the disorder.

Duke Scholars

Published In

Int J Geriatr Psychiatry

DOI

EISSN

1099-1166

Publication Date

November 2011

Volume

26

Issue

11

Start / End Page

1101 / 1108

Location

England

Related Subject Headings

  • Reproducibility of Results
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Depressive Disorder
  • Cerebrovascular Disorders
  • 5203 Clinical and health psychology
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Culang-Reinlieb, M. E., Johnert, L. C., Brickman, A. M., Steffens, D. C., Garcon, E., & Sneed, J. R. (2011). MRI-defined vascular depression: a review of the construct. Int J Geriatr Psychiatry, 26(11), 1101–1108. https://doi.org/10.1002/gps.2668
Culang-Reinlieb, Michelle E., Lauren C. Johnert, Adam M. Brickman, David C. Steffens, Ernst Garcon, and Joel R. Sneed. “MRI-defined vascular depression: a review of the construct.Int J Geriatr Psychiatry 26, no. 11 (November 2011): 1101–8. https://doi.org/10.1002/gps.2668.
Culang-Reinlieb ME, Johnert LC, Brickman AM, Steffens DC, Garcon E, Sneed JR. MRI-defined vascular depression: a review of the construct. Int J Geriatr Psychiatry. 2011 Nov;26(11):1101–8.
Culang-Reinlieb, Michelle E., et al. “MRI-defined vascular depression: a review of the construct.Int J Geriatr Psychiatry, vol. 26, no. 11, Nov. 2011, pp. 1101–08. Pubmed, doi:10.1002/gps.2668.
Culang-Reinlieb ME, Johnert LC, Brickman AM, Steffens DC, Garcon E, Sneed JR. MRI-defined vascular depression: a review of the construct. Int J Geriatr Psychiatry. 2011 Nov;26(11):1101–1108.

Published In

Int J Geriatr Psychiatry

DOI

EISSN

1099-1166

Publication Date

November 2011

Volume

26

Issue

11

Start / End Page

1101 / 1108

Location

England

Related Subject Headings

  • Reproducibility of Results
  • Magnetic Resonance Imaging
  • Humans
  • Geriatrics
  • Depressive Disorder
  • Cerebrovascular Disorders
  • 5203 Clinical and health psychology
  • 4203 Health services and systems
  • 3202 Clinical sciences
  • 1702 Cognitive Sciences