Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.

Journal Article (Journal Article)

OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject. RESULTS: In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension. CONCLUSIONS: The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.

Full Text

Duke Authors

Cited Authors

  • Steffens, DC; Taylor, WD; McQuoid, DR; Krishnan, KRR

Published Date

  • March 2008

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 244 - 248

PubMed ID

  • 17702053

International Standard Serial Number (ISSN)

  • 0885-6230

Digital Object Identifier (DOI)

  • 10.1002/gps.1869


  • eng

Conference Location

  • England