Short/long heterozygotes at 5HTTLPR and white matter lesions in geriatric depression.
Journal Article
OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject. RESULTS: In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension. CONCLUSIONS: The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
Full Text
Duke Authors
Cited Authors
- Steffens, DC; Taylor, WD; McQuoid, DR; Krishnan, KRR
Published Date
- March 2008
Published In
Volume / Issue
- 23 / 3
Start / End Page
- 244 - 248
PubMed ID
- 17702053
Pubmed Central ID
- 17702053
International Standard Serial Number (ISSN)
- 0885-6230
Digital Object Identifier (DOI)
- 10.1002/gps.1869
Language
- eng
Conference Location
- England