Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects.

Journal Article (Journal Article)

To study patterns of iron deposition in the putamen in aging, we reviewed brain magnetic resonance imaging (MRI) scans of 56 normal subjects. We developed the Signal Hypointensity in the Putamen (SHIP) Scale, a semiquantitative measure, to evaluate putamen nuclei for extent of iron deposition relative to the globus pallidus. The SHIP score was highly reliable (kappa = 0.76) and significantly correlated with age (P < 0.0001). We found that age-related iron deposition in putamen nuclei follows a characteristic pattern along a posterolateral-to-anteromedial gradient. This gradient may be related to the microvasculature of the putamen. Other studies are needed to replicate our findings in patients with affective and other neuropsychiatric disorders and to clarify the pathophysiological mechanisms that govern these changes.

Full Text

Duke Authors

Cited Authors

  • Steffens, DC; McDonald, WM; Tupler, LA; Boyko, OB; Krishnan, KR

Published Date

  • November 25, 1996

Published In

Volume / Issue

  • 68 / 1

Start / End Page

  • 55 - 61

PubMed ID

  • 9027933

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0925-4927(96)02834-x


  • eng

Conference Location

  • Ireland