Calcineurin pathway inhibition: A novel antifungal strategy
As the burden of invasive fungal infection increases, newer strategies for the development of antifungal agents are needed. Numerous studies on the existing classes of available antifungals have not yielded optimal treatments, suggesting that a novel and unique approach is warranted. The calcineurin pathway is a stress-response mechanism employed by fungi. The present author's work suggests that harnessing this critical pathway can lead to the killing of Aspergillus fumigatus, one of the deadliest fungal pathogens. In this article, the calcineurin pathway in fungi and the efforts to use calcineurin pathway inhibition as a means of antifungal attack are reviewed.