Chronic neutropenia: diagnostic approach and prognosis.

Journal Article (Journal Article)

Chronic neutropenia is a term used to describe a group of disorders characterized by a persistent neutrophil count of less than 1500 cells/microliters. We studied seven children and three sets of parents. We separated patients into a group with good prognosis and a group at higher risk of infection by using a combination of tests, including bone marrow aspiration and biopsy, steroid stimulation of bone marrow reserve, and in vitro CFU-GM and CSA assays. Children with a normal number of myeloid elements in their bone marrow and a normal bone marrow response to steroid stimulation had a benign course. CFU-GM and CSA assays helped to classify these children's neutropenia when their bone marrow had decreased numbers of myeloid elements. Family studies in three children were consistent with an inherited neutropenia, even when their parents were hematologically normal.

Full Text

Duke Authors

Cited Authors

  • de Alarcon, PA; Goldberg, J; Nelson, DA; Stockman, JA

Published Date

  • 1983

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 3 - 9

PubMed ID

  • 6602565

International Standard Serial Number (ISSN)

  • 0192-8562


  • eng

Conference Location

  • United States