Neutropenia, fever, and infection in children with acute lymphocytic leukemia.

Journal Article (Journal Article)

In an attempt to determine the relationship between neutropenia (absolute granulocyte count less than 1,000/cu mm), infection, and disease status, 20 patients with acute lymphoblastic leukemia were observed for a total of 34 patient-years. Febrile episodes occurred with much greater frequency in patients during the course of treatment induction (0.9/mo), or while in relapse (2.46/mo) than while in remission (0.19/mo). A cause for fever was identified much more frequently in patients in remission, both when neutropenic and nonneutropenic. When absolute granulocyte counts fell below 200/cu mm, a cause for fever was generally identified regardless of disease status. We propose that the majority of febrile episodes in patients at the time of induction of treatment or in relapse with neutrophil counts of more than 200/cu mm are caused by the disease process rather than secondary to a diagnosable infection.

Full Text

Duke Authors

Cited Authors

  • Wolk, JA; Stuart, MJ; Stockman, JA; Oski, FA

Published Date

  • February 1, 1977

Published In

Volume / Issue

  • 131 / 2

Start / End Page

  • 157 - 158

PubMed ID

  • 264764

International Standard Serial Number (ISSN)

  • 0002-922X

Digital Object Identifier (DOI)

  • 10.1001/archpedi.1977.02120150039007


  • eng

Conference Location

  • United States