Iron deficiency anemia and increased urinary norepinephrine excretion.

Published

Journal Article

Chronic iron deficiency in rats resulted in decreased MAO activity both in vitro and in vivo. Since MAO is an important enzyme in inactivation of catecholamines, urinary excretion of DA, NE, E, MN-NMN, and VMA was measured in 24-hour samples from 11 iron-deficient children before and after treatment with intramuscular iron. Pretreatment NE excretion was abnormally high and returned to normal (P=0.001) within one week of therapy. VMA excretion also was higher before than after treatment (P greater than 0.05), but most values were within the normal range for healthy children of comparable size. There was no significant difference between DA, E, and MN-NMN excretion before and after iron therapy. Anemic, non-iron-deficient children had normal urinary NE, E, and VMA excretion before and after transfusion. These findings suggest that the irritability, lack of attentiveness, and low performance scores of iron-deficient children may be related to alterations in catecholamine metabolic pathways secondary to dependence of MAO on adequate iron stores.

Full Text

Duke Authors

Cited Authors

  • Voorhess, ML; Stuart, MJ; Stockman, JA; Oski, FA

Published Date

  • April 1, 1975

Published In

Volume / Issue

  • 86 / 4

Start / End Page

  • 542 - 547

PubMed ID

  • 1127500

Pubmed Central ID

  • 1127500

International Standard Serial Number (ISSN)

  • 0022-3476

Digital Object Identifier (DOI)

  • 10.1016/s0022-3476(75)80144-2

Language

  • eng

Conference Location

  • United States