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Building and maintaining the epithelium of the lung.

Publication ,  Journal Article
Rackley, CR; Stripp, BR
Published in: J Clin Invest
August 2012

Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. Advances in cell isolation, in vitro culture techniques, and genetic manipulation of animal models have increased our understanding of the development and maintenance of the pulmonary epithelium. This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life.

Duke Scholars

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

August 2012

Volume

122

Issue

8

Start / End Page

2724 / 2730

Location

United States

Related Subject Headings

  • Respiratory Mucosa
  • Pulmonary Gas Exchange
  • Models, Animal
  • Mice
  • Lung
  • Immunology
  • Humans
  • Epithelial Cells
  • Body Patterning
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rackley, C. R., & Stripp, B. R. (2012). Building and maintaining the epithelium of the lung. J Clin Invest, 122(8), 2724–2730. https://doi.org/10.1172/JCI60519
Rackley, Craig R., and Barry R. Stripp. “Building and maintaining the epithelium of the lung.J Clin Invest 122, no. 8 (August 2012): 2724–30. https://doi.org/10.1172/JCI60519.
Rackley CR, Stripp BR. Building and maintaining the epithelium of the lung. J Clin Invest. 2012 Aug;122(8):2724–30.
Rackley, Craig R., and Barry R. Stripp. “Building and maintaining the epithelium of the lung.J Clin Invest, vol. 122, no. 8, Aug. 2012, pp. 2724–30. Pubmed, doi:10.1172/JCI60519.
Rackley CR, Stripp BR. Building and maintaining the epithelium of the lung. J Clin Invest. 2012 Aug;122(8):2724–2730.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

August 2012

Volume

122

Issue

8

Start / End Page

2724 / 2730

Location

United States

Related Subject Headings

  • Respiratory Mucosa
  • Pulmonary Gas Exchange
  • Models, Animal
  • Mice
  • Lung
  • Immunology
  • Humans
  • Epithelial Cells
  • Body Patterning
  • Animals