Building and maintaining the epithelium of the lung.


Journal Article (Review)

Airspaces of the lung are lined by an epithelium whose cellular composition changes along the proximal-to-distal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas exchange. Advances in cell isolation, in vitro culture techniques, and genetic manipulation of animal models have increased our understanding of the development and maintenance of the pulmonary epithelium. This review discusses basic cellular mechanisms that regulate establishment of the conducting airway and gas exchange systems as well as the functional maintenance of the epithelium during postnatal life.

Full Text

Duke Authors

Cited Authors

  • Rackley, CR; Stripp, BR

Published Date

  • August 2012

Published In

Volume / Issue

  • 122 / 8

Start / End Page

  • 2724 - 2730

PubMed ID

  • 22850882

Pubmed Central ID

  • 22850882

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI60519


  • eng

Conference Location

  • United States