Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.

Journal Article

Alzheimer's disease patients have increased frequency of apolipoprotein E allele c4, suggesting apoE4 is a risk factor determining disease. ApoE binds A beta amyloid peptide with great avidity in vitro and in the neuritic plaque. Potentially, binding of A beta to apolipoprotein E could increase A beta neurotoxicity. However, in hippocampal cultures, 0.1 microM apolipoprotein E eliminated the neurotoxicity of 10 microM A beta. Neuronal rescue was dose-dependent and occurred even after 48 hours exposure to A beta, but was overwhelmed by excess A beta. Thus, interaction between these proteins does not directly increase A beta neurotoxicity, and the role of ApoE in Alzheimer's disease remains to be elucidated.

Full Text

Duke Authors

Cited Authors

  • Whitson, JS; Mims, MP; Strittmatter, WJ; Yamaki, T; Morrisett, JD; Appel, SH

Published Date

  • February 28, 1994

Published In

Volume / Issue

  • 199 / 1

Start / End Page

  • 163 - 170

PubMed ID

  • 8123007

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1006/bbrc.1994.1209

Language

  • eng

Conference Location

  • United States