Antidote control of aptamer therapeutics: the road to a safer class of drug agents.
Journal Article (Journal Article;Review)
Aptamers, or nucleic acid ligands, have gained clinical interest over the past 20 years due to their unique characteristics, which are a combination of the best facets of small molecules and antibodies. The high binding affinity and specificity of aptamers allows for isolation of an artificial ligand for theoretically any therapeutic target of interest. Chemical manipulations of aptamers also allow for fine-tuning of their bioavailability, and antidote control greatly expands their clinical use. Here we review the various methods of antidote control of aptamer therapeutics--matched oligonucleotide antidotes and universal antidotes. We also describe the development, recent progress, and potential future therapeutic applications of these types of aptamer-antidote pairs.
Full Text
Duke Authors
Cited Authors
- Bompiani, KM; Woodruff, RS; Becker, RC; Nimjee, SM; Sullenger, BA
Published Date
- August 2012
Published In
Volume / Issue
- 13 / 10
Start / End Page
- 1924 - 1934
PubMed ID
- 22352726
Electronic International Standard Serial Number (EISSN)
- 1873-4316
Digital Object Identifier (DOI)
- 10.2174/138920112802273137
Language
- eng
Conference Location
- Netherlands