The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.
Journal Article (Journal Article;Review)
Effective therapeutic utilization of antisense and siRNA oligonucleotides represents a major challenge to drug delivery science. Although many strategies and technologies have been applied to oligonucleotide delivery, a key issue remains the role of molecular or carrier size. In this brief review, we address some of the size-related parameters that regulate the biodistribution of oligonucleotides. We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery.
Full Text
Duke Authors
Cited Authors
- Huang, L; Sullenger, B; Juliano, R
Published Date
- September 2010
Published In
Volume / Issue
- 18 / 8
Start / End Page
- 567 - 574
PubMed ID
- 20367081
Electronic International Standard Serial Number (EISSN)
- 1029-2330
Digital Object Identifier (DOI)
- 10.3109/10611861003734019
Language
- eng
Conference Location
- England