The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.

Journal Article (Journal Article;Review)

Effective therapeutic utilization of antisense and siRNA oligonucleotides represents a major challenge to drug delivery science. Although many strategies and technologies have been applied to oligonucleotide delivery, a key issue remains the role of molecular or carrier size. In this brief review, we address some of the size-related parameters that regulate the biodistribution of oligonucleotides. We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Sullenger, B; Juliano, R

Published Date

  • September 2010

Published In

Volume / Issue

  • 18 / 8

Start / End Page

  • 567 - 574

PubMed ID

  • 20367081

Electronic International Standard Serial Number (EISSN)

  • 1029-2330

Digital Object Identifier (DOI)

  • 10.3109/10611861003734019

Language

  • eng

Conference Location

  • England