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The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.

Publication ,  Journal Article
Huang, L; Sullenger, B; Juliano, R
Published in: J Drug Target
September 2010

Effective therapeutic utilization of antisense and siRNA oligonucleotides represents a major challenge to drug delivery science. Although many strategies and technologies have been applied to oligonucleotide delivery, a key issue remains the role of molecular or carrier size. In this brief review, we address some of the size-related parameters that regulate the biodistribution of oligonucleotides. We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery.

Duke Scholars

Published In

J Drug Target

DOI

EISSN

1029-2330

Publication Date

September 2010

Volume

18

Issue

8

Start / End Page

567 / 574

Location

England

Related Subject Headings

  • RNA, Small Interfering
  • Pharmacology & Pharmacy
  • Particle Size
  • Oligonucleotides, Antisense
  • Nanoparticles
  • Liposomes
  • Humans
  • Glomerular Filtration Rate
  • Endothelial Cells
  • Drug Carriers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, L., Sullenger, B., & Juliano, R. (2010). The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target, 18(8), 567–574. https://doi.org/10.3109/10611861003734019
Huang, Leaf, Bruce Sullenger, and Rudy Juliano. “The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.J Drug Target 18, no. 8 (September 2010): 567–74. https://doi.org/10.3109/10611861003734019.
Huang L, Sullenger B, Juliano R. The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target. 2010 Sep;18(8):567–74.
Huang, Leaf, et al. “The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.J Drug Target, vol. 18, no. 8, Sept. 2010, pp. 567–74. Pubmed, doi:10.3109/10611861003734019.
Huang L, Sullenger B, Juliano R. The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides. J Drug Target. 2010 Sep;18(8):567–574.

Published In

J Drug Target

DOI

EISSN

1029-2330

Publication Date

September 2010

Volume

18

Issue

8

Start / End Page

567 / 574

Location

England

Related Subject Headings

  • RNA, Small Interfering
  • Pharmacology & Pharmacy
  • Particle Size
  • Oligonucleotides, Antisense
  • Nanoparticles
  • Liposomes
  • Humans
  • Glomerular Filtration Rate
  • Endothelial Cells
  • Drug Carriers