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Aptamers in the clinic

Publication ,  Journal Article
Nimjee, SM; Sullenger, BA
Published in: Drugs of the Future
November 1, 2009

In 1990, an RNA molecule was designed that bound to a nucleic acid binding protein to act as a decoy, thereby preventing HIV replication. That same year, two research groups identified a high-throughput method to select for nucleic acids to protein targets and the field of aptamer therapeutics was born. Over the last 20 years, numerous aptamers to therapeutic targets have been isolated and undergone in vitro and ex vivo analysis before in vivo testing. Aptamer therapeutics represents a promising new class of agents to treat disease. The capability to extensively modify these compounds provides a potential broader spectrum of clinical applications than antibodies and small molecules. A brief historical review of aptamers is presented and the therapeutic aptamers currently in clinical development are described. Copyright © 2009 Prous Science, S.A.U. or its licensors. All rights reserved.

Duke Scholars

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

November 1, 2009

Volume

34

Issue

11

Start / End Page

897 / 901

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Chicago
ICMJE
MLA
NLM
Nimjee, S. M., & Sullenger, B. A. (2009). Aptamers in the clinic. Drugs of the Future, 34(11), 897–901. https://doi.org/10.1358/dof.2009.34.11.1436007
Nimjee, S. M., and B. A. Sullenger. “Aptamers in the clinic.” Drugs of the Future 34, no. 11 (November 1, 2009): 897–901. https://doi.org/10.1358/dof.2009.34.11.1436007.
Nimjee SM, Sullenger BA. Aptamers in the clinic. Drugs of the Future. 2009 Nov 1;34(11):897–901.
Nimjee, S. M., and B. A. Sullenger. “Aptamers in the clinic.” Drugs of the Future, vol. 34, no. 11, Nov. 2009, pp. 897–901. Scopus, doi:10.1358/dof.2009.34.11.1436007.
Nimjee SM, Sullenger BA. Aptamers in the clinic. Drugs of the Future. 2009 Nov 1;34(11):897–901.

Published In

Drugs of the Future

DOI

ISSN

0377-8282

Publication Date

November 1, 2009

Volume

34

Issue

11

Start / End Page

897 / 901

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences