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Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast.

Publication ,  Journal Article
Nunes, LW; Schnall, MD; Siegelman, ES; Langlotz, CP; Orel, SG; Sullivan, D; Muenz, LA; Reynolds, CA; Torosian, MH
Published in: AJR Am J Roentgenol
August 1997

OBJECTIVE: Our objective was twofold: to determine which architectural features revealed by high spatial-resolution MR imaging of the breast contribute to diagnostic accuracy and to evaluate the diagnostic performance characteristics of those architectural features. MATERIALS AND METHODS: Eligible patients with suspicious mammographic or palpable findings or both underwent MR imaging. Ninety-three patients whose MR images revealed lesions that corresponded to the mammographically visible or palpable findings were included in the study. Patients were examined with sagittal T1-weighted spin-echo MR imaging, fat-saturated T2-weighted fast spin-echo MR imaging, and dynamically enhanced fat-saturated fast gradient-echo MR imaging. All patients underwent subsequent excisional biopsy or cyst aspiration. Lesions were identified initially by an experienced radiologist who was aware of the patient's clinical or mammographic information. Two radiologists who were unaware of the patients' histories and who had less experience in MR imaging of the breast then independently evaluated each lesion for the architectural-features and predicted each lesion's potential for malignancy. RESULTS: Architectural features that were highly predictive of benign disease included smooth or lobulated borders (97-100%), the absence of mass enhancement (100%), and enhancement that was less than the enhancement of surrounding breast fibroglandular tissue (93-100%). Nonenhancing internal septations were specific for the diagnosis of fibroadenoma. Architectural features that were highly predictive of malignant disease included spiculated borders (76-88%) and peripheral rim enhancement in the presence of central lesion enhancement (79-92%). CONCLUSION: Architectural features revealed by high spatial-resolution MR imaging of the breast can help distinguish benign from malignant disease.

Duke Scholars

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

August 1997

Volume

169

Issue

2

Start / End Page

409 / 415

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • ROC Curve
  • Predictive Value of Tests
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Gadolinium DTPA
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nunes, L. W., Schnall, M. D., Siegelman, E. S., Langlotz, C. P., Orel, S. G., Sullivan, D., … Torosian, M. H. (1997). Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast. AJR Am J Roentgenol, 169(2), 409–415. https://doi.org/10.2214/ajr.169.2.9242744
Nunes, L. W., M. D. Schnall, E. S. Siegelman, C. P. Langlotz, S. G. Orel, D. Sullivan, L. A. Muenz, C. A. Reynolds, and M. H. Torosian. “Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast.AJR Am J Roentgenol 169, no. 2 (August 1997): 409–15. https://doi.org/10.2214/ajr.169.2.9242744.
Nunes LW, Schnall MD, Siegelman ES, Langlotz CP, Orel SG, Sullivan D, et al. Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast. AJR Am J Roentgenol. 1997 Aug;169(2):409–15.
Nunes, L. W., et al. “Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast.AJR Am J Roentgenol, vol. 169, no. 2, Aug. 1997, pp. 409–15. Pubmed, doi:10.2214/ajr.169.2.9242744.
Nunes LW, Schnall MD, Siegelman ES, Langlotz CP, Orel SG, Sullivan D, Muenz LA, Reynolds CA, Torosian MH. Diagnostic performance characteristics of architectural features revealed by high spatial-resolution MR imaging of the breast. AJR Am J Roentgenol. 1997 Aug;169(2):409–415.

Published In

AJR Am J Roentgenol

DOI

ISSN

0361-803X

Publication Date

August 1997

Volume

169

Issue

2

Start / End Page

409 / 415

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • ROC Curve
  • Predictive Value of Tests
  • Pentetic Acid
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Gadolinium DTPA