Therapy with mycophenolate mofetil for refractory acute and chronic GVHD.

Published

Journal Article

We evaluated the pharmacokinetics and efficacy of oral mycophenolate mofetil (MMF) for treatment of refractory GVHD. In a prospective study of acute GVHD, 9 of 19 patients (47%) had a response and 10 (53%) had no improvement. Survival at 6 and 12 months after the start of MMF was 37 and 16%, respectively. In a retrospective study of acute GVHD, 14 of 29 patients (48%) had a response and 15 (52%) had no improvement. Survival at 6 and 12 months was 55 and 52%, respectively. In a prospective study of chronic GVHD, the cumulative incidence of disease resolution and withdrawal of all systemic immunosuppressive treatment was 9, 17 and 26% at 12, 24 and 36 months, respectively, after starting MMF. Thirteen patients (59%) required additional systemic immunosuppressive treatment for chronic GVHD. Nine of the 42 patients (21%) in the prospective studies discontinued MMF treatment because of toxicity. The area under the curve plasma concentrations of mycophenolic acid seemed to be suboptimal among patients with acute GVHD but not among those with chronic GVHD. MMF can be used effectively for treatment of GVHD.

Full Text

Duke Authors

Cited Authors

  • Furlong, T; Martin, P; Flowers, MED; Carnevale-Schianca, F; Yatscoff, R; Chauncey, T; Appelbaum, FR; Deeg, HJ; Doney, K; Witherspoon, R; Storer, B; Sullivan, KM; Storb, R; Nash, RA

Published Date

  • December 2009

Published In

Volume / Issue

  • 44 / 11

Start / End Page

  • 739 - 748

PubMed ID

  • 19377515

Pubmed Central ID

  • 19377515

Electronic International Standard Serial Number (EISSN)

  • 1476-5365

Digital Object Identifier (DOI)

  • 10.1038/bmt.2009.76

Language

  • eng

Conference Location

  • England