Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.


Journal Article

Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.

Full Text

Duke Authors

Cited Authors

  • Eggleston, B; Patience, M; Edwards, S; Adamkiewicz, T; Buchanan, GR; Davies, SC; Dickerhoff, R; Donfield, S; Feig, SA; Giller, RH; Haight, A; Horan, J; Hsu, LL; Kamani, N; Lane, P; Levine, JE; Margolis, D; Moore, TB; Ohene-Frempong, K; Redding-Lallinger, R; Roberts, IAG; Rogers, ZR; Sanders, JE; Scott, JP; Sleight, B; Thompson, AA; Sullivan, KM; Walters, MC; Multicenter Study of HCT for SCA,

Published Date

  • February 2007

Published In

Volume / Issue

  • 136 / 4

Start / End Page

  • 673 - 676

PubMed ID

  • 17223910

Pubmed Central ID

  • 17223910

International Standard Serial Number (ISSN)

  • 0007-1048

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2141.2006.06486.x


  • eng

Conference Location

  • England