Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.
(Journal Article;Multicenter Study)
Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt.
Eggleston, B; Patience, M; Edwards, S; Adamkiewicz, T; Buchanan, GR; Davies, SC; Dickerhoff, R; Donfield, S; Feig, SA; Giller, RH; Haight, A; Horan, J; Hsu, LL; Kamani, N; Lane, P; Levine, JE; Margolis, D; Moore, TB; Ohene-Frempong, K; Redding-Lallinger, R; Roberts, IAG; Rogers, ZR; Sanders, JE; Scott, JP; Sleight, B; Thompson, AA; Sullivan, KM; Walters, MC; Multicenter Study of HCT for SCA,
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)