Pathophysiology and treatment of graft-versus-host disease

Journal Article

Acute graft-versus-host disease denotes a distinctive syndrome characterized by a triad of dermatitis (rash), hepatitis (jaundice), and gastroenteritis (abdominal pain, diarrhea) developing in the first 100 days after allogeneic hematopoietic cell transplantation. Chronic graft-versus- host disease designates a more diverse syndrome, usually presenting with multiorgan involvement and commonly developing 100 days after hematopoietic cell transplantation. This article discusses the pathophysiology, incidence and predictive factors, clinical manifestations, diagnosis and grading, prevention, and treatment for both types of the disease.

Full Text

Duke Authors

Cited Authors

  • Flowers, MED; Kansu, E; Sullivan, KM

Published Date

  • 1999

Published In

Volume / Issue

  • 13 / 5

Start / End Page

  • 1091 - 1112

PubMed ID

  • 10553263

International Standard Serial Number (ISSN)

  • 0889-8588

Digital Object Identifier (DOI)

  • 10.1016/S0889-8588(05)70111-8