Marrow transplantation from HLA-matched unrelated donors for treatment of hematologic malignancies.

Journal Article (Journal Article)

Less than 40% of the patients who could benefit from marrow transplantation have an HLA-matched relative who can serve as a donor. For this reason, several centers have explored marrow transplantation from other categories of donors. This retrospective study analyzes the results of marrow transplantation for 52 patients receiving grafts from HLA-A,B,DR,Dw-phenotypically matched, MLC-compatible, unrelated volunteer donors compared to a disease, disease-stage, and age-matched cohort of 104 patients transplanted from HLA-genotypically identical sibling donors. The patients transplanted from unrelated donors had an increased incidence of grade II-IV acute graft-versus-host disease compared to patients transplanted from related donors (79% vs. 36%, P much less than 0.001). However, the probability of relapse-free survival appears similar in the two groups (P = 0.39 over all, with estimates of 41% vs. 46% at 1 year). We conclude from this preliminary data that marrow transplantation from HLA-matched unrelated donors should be considered in most, if not all, circumstances where transplantation from an HLA-matched sibling would be indicated if such a donor were available.

Full Text

Duke Authors

Cited Authors

  • Beatty, PG; Hansen, JA; Longton, GM; Thomas, ED; Sanders, JE; Martin, PJ; Bearman, SI; Anasetti, C; Petersdorf, EW; Mickelson, EM

Published Date

  • February 1991

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 443 - 447

PubMed ID

  • 1994541

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-199102000-00034


  • eng

Conference Location

  • United States