Disordered salivary immunoglobulin secretion and sodium transport in human chronic graft-versus-host disease.

Published

Journal Article

Whole saliva samples and lip biopsies were collected from 12 allogeneic bone marrow transplant recipients who developed extensive chronic graft-versus-host disease (GVHD) and from 10 healthy allogeneic and syngeneic recipients without GVHD. Six of ten biopsies from patients with chronic GVHD had lichenoid stomatitis or sialadenitis, or both, with sialodochitis. Seven of nine biopsies from patients free of chronic GVHD were entirely normal, and two had either mild glandular or mucosal changes. Salivary gland involvement in chronic GVHD was associated with decreased or absent levels of salivary IgA and inorganic phosphate, decreased salivary flow rates, and increased concentrations of salivary sodium, albumin, and IgG. The most striking abnormalities were found in patients with histologic evidence of sialadenitis. In contrast, marrow transplant recipients without chronic GVHD had normal salivary immunoglobulin and electrolyte levels. Secretory IgA deficiency may contribute to the frequent sinobronchial infections observed in patients with chronic GVHD.

Full Text

Duke Authors

Cited Authors

  • Izutsu, KT; Sullivan, KM; Schubert, MM; Truelove, EL; Shulman, HM; Sale, GE; Morton, TH; Rice, JC; Witherspoon, RP; Storb, R; Thomas, ED

Published Date

  • May 1, 1983

Published In

Volume / Issue

  • 35 / 5

Start / End Page

  • 441 - 446

PubMed ID

  • 6342224

Pubmed Central ID

  • 6342224

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-198305000-00010

Language

  • eng

Conference Location

  • United States