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Recombinant leukocyte A interferon for the treatment of serious viral infections after marrow transplant: a phase I study.

Publication ,  Journal Article
Meyers, JD; Day, LM; Lum, LG; Sullivan, KM
Published in: J Infect Dis
September 1983

Six marrow-transplant patients with serious virus infections (four with cytomegalovirus and two with adenovirus) were treated with recombinant leukocyte alpha interferon at daily doses of 6,000,000-50,000,000 units to determine safety and tolerance. Fever and gastrointestinal side effects attributable to interferon occurred in two patients each. Hepatic function abnormalities were observed in all six patients, although five had such abnormalities before treatment. Treatment of one patient was stopped because of apparent suppression of marrow activity. Natural cytotoxic activity increased in the four patients treated for cytomegalovirus infection. All six patients died of pneumonia, with four proven to have cytomegalovirus-related pneumonia at autopsy. Except for the presence of abnormal hepatic function, recombinant leukocyte alpha interferon was well tolerated after marrow transplantation. Efficacy remains to be established in treatment or prophylactic trials.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1983

Volume

148

Issue

3

Start / End Page

551 / 556

Location

United States

Related Subject Headings

  • Microbiology
  • Male
  • Liver
  • Leukopenia
  • Interferon Type I
  • Humans
  • Female
  • Drug Evaluation
  • Cytotoxicity, Immunologic
  • Cytomegalovirus Infections
 

Citation

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MLA
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Meyers, J. D., Day, L. M., Lum, L. G., & Sullivan, K. M. (1983). Recombinant leukocyte A interferon for the treatment of serious viral infections after marrow transplant: a phase I study. J Infect Dis, 148(3), 551–556. https://doi.org/10.1093/infdis/148.3.551
Meyers, J. D., L. M. Day, L. G. Lum, and K. M. Sullivan. “Recombinant leukocyte A interferon for the treatment of serious viral infections after marrow transplant: a phase I study.J Infect Dis 148, no. 3 (September 1983): 551–56. https://doi.org/10.1093/infdis/148.3.551.
Meyers, J. D., et al. “Recombinant leukocyte A interferon for the treatment of serious viral infections after marrow transplant: a phase I study.J Infect Dis, vol. 148, no. 3, Sept. 1983, pp. 551–56. Pubmed, doi:10.1093/infdis/148.3.551.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

September 1983

Volume

148

Issue

3

Start / End Page

551 / 556

Location

United States

Related Subject Headings

  • Microbiology
  • Male
  • Liver
  • Leukopenia
  • Interferon Type I
  • Humans
  • Female
  • Drug Evaluation
  • Cytotoxicity, Immunologic
  • Cytomegalovirus Infections